Celebrating Rare Disease Day with our colleagues at the BioISI research unit, at the Faculty of Sciences, University of Lisbon.
More on rare disorders in our research unit: https://bioisi.pt/biorscide-science-days-and-ephemeris-rare-disease-day/
A focus on rare neurodegenerative disorders
Alzheimer and Parkinson diseases are the most common and famous neurodegenerative disorders. However, most neurodegenerative disorders are rare and largely disregarded by the pharmaceutical industry. We are developing molecular tools and cellular models to study some of them, such as Huntington and Alexander diseases, ARSACS and SPAX8. Huntington´s disease Huntington’s disease (HD) is a neurodegenerative […]
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Response to injury: the STAT3 transcription factor
This pleiotropic transcription factor is involved in the regulation of cell survival, proliferation and differentiation in normal conditions, but also in pathological conditions as diverse as inflammation, neurodegenerative disorders, stroke, traumatic brain injury, radiation toxicity or cancer. We are studying the role of protein-protein interactions and post-translational modifications in its functions at a cellular level.
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Protein complementation as a tool
Proteins can be split in two or more non-functional fragments that reconstitute their function when they are brought together. This property of proteins has been applied to fluorescent proteins and other reporters to study interactions between biomolecules. However, it can also be useful to treat a wide number of human disorders.
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