Projects

Ongoing

2021-2024

 

Title: Viscoelastic cells: new experimental approaches based on atomic force microscopy.
Source: Portuguese Foundation for Science and Technology (FCT, PTDC/FIS-MAC/2741/2021).
Role: Co-Principal Investigator.
Funds: 248.689 euros
 

2021 Title: Mechanistic and viscoelastic properties of cells with defective intermediate filament networks: a role for the chaperone sacsin.
Source: BioISI Research Unit (Biosystems and Integrative Sciences Institute).
Role: Principal Investigator.
Funds: 7.500 euros

2018-2021 Title: Mechanistic and optogenetic control of astroglia for neural repair.
Source: Portuguese Foundation for Science and Technology (FCT, PTDC/MED-NEU/31417/2017).
Role: Principal Investigator.
Funds: 239.000 euros
 

Inactive

2020 Title: Restoring NKX6-2 function by protein complementation: a proof-of concept.
Source: BioISI Research Unit (Biosystems and Integrative Sciences Institute).
Role: Principal Investigator.
Funds: 10.000 euros
 

2016-2019 Title: Nanoheaters and nanothermometers playing together: towards applications in Brownian motion and hyperthermia.
Source: Portuguese Foundation for Science and Technology (FCT, PTDC/CTM-NAN/4647/2014).
Role: Participant.
Funds: 184.000 euros
 

 

2015-2017 Title: Differences in tumor metabolism and its regulation by miRNA as the keystone to understand distinct antitumoral effects of melatonin and other natural compounds.
Source: Ministry of economy and competence, Spain (SAF2014-58468-R).
Role: Participant.
Funds: 120.000 euros
 

2014 Title: Understanding and controlling astrogliogenesis for the success of regenerative medicine in the central nervous system.
Source: Exploratory Project Associated to FCT investigator contract (IF/00094/2013/CP1173/CT0005).
Role: Principal investigator.
Funds: 50.000 euros
 

2012-2013 Title: The role of phosphorylation pathways in the oligomerization and toxicity of mutant huntingtin.
Source: Seed Funds, European Huntington´s Disease Network (EHDN).
Role: Co-Principal investigator.
Funds: 50.000 euros
 

2010-2013 Title: Modulation of amyloid beta-induced neuronal toxicity via JNK: a novel role for tauroursodeoxycholic acid.
Source: Portuguese Foundation for Science and Technology (FCT, PTDC/SAU-NMC/112636/2009).
Role: Participant.
Funds: 98.000 euros
 

2010-2013 Title: Signaling pathways involved in the cytotoxic effect of melatonin on glioma cancer stem cells.
Source: Spanish Ministry of Science and Innovation (SAF2010-21729).
Role: Participant.
Funds: 92.380 euros
 

2006-2008

 

Title: Phosphorylation pathways involved in neural precursor cell differentiation.
Source: Fondo de Investigaciones Sanitarias, Ministry of Health and Consumption/CSIC/Salk Institute (SALK 06/02).
Role: Principal Investigator.
Funds: 30.000 euros
 

2003-2006 Title: Melatonin oncostatic effects on central nervous system tumours: in vitro and in vivo studies.
Source: Fondo de Investigaciones Sanitarias, Ministry of Health and Consumption (FISS-04-PI03/1596).
Role: Participant.
Funds: 136.965 euros
 

2003-2006 Title: Reentry of neurons in the cell cycle as a mediator between oxidative stress and apoptosis in neurodegenerative disorders: protective role of antioxidants.
Source: Ministry of Science and Technology (MCT-03-SAF-03303).
Role: Participant.
Funds: 115.000 euros
 

2003-2005 Title: Relationship between oxidative stress, cell cycle and apoptosis in Parkinson´s disease: protective role of antioxidants and cell cycle inhibitors.
Source: Government of the Principado de Asturias (PB02-085).
Role: Participant.
Funds: 35.280 euros